- Oil & Gas Companies, South Lyon
- Oil Change & Lubrication, South Lyon - Auto Oil & Quick Lube
- Oil Industry & Oil Field Equipment & Services, South Lyon - Oil Companies
- Oils Hydraulic, South Lyon
- Ophthalmic Goods, South Lyon
- Ophthalmologists, South Lyon - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Goods Manufacturers, South Lyon
- Optical Instruments & Lenses Manufacturers, South Lyon
- Optical Stores - Eyeglasses, Lenses & Sunglasses, South Lyon
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- Opticians, South Lyon
- Optometrists, South Lyon - Eye Doctors, Physicians & Surgeons (Optometry)
- Oral Surgeon, South Lyon - Dentists - Oral & Maxillofacial Surgeons
- Ornamental Greenhouses, South Lyon
- Ornamental Nursery, South Lyon
- Ornamental Nursery Services, South Lyon
- Orthodontist, South Lyon - Teeth Straightening, Invisalign & Dental Braces
- Osteoporosis Doctors, South Lyon - Physicians & Surgeons
- Outdoor & Lawn & Garden Equipment Repair & Service, South Lyon
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