- Sand Gravel & Aggregate, South Lyon
- Sandwich Shop Restaurants, South Lyon
- Satellite & Cable TV Equipment & Systems Repair & Service, South Lyon
- Satellite Dish Antennas & Equipment Dealers, South Lyon
- Satellite TV Service, South Lyon
- Scrap & Waste Materials, South Lyon
- Screen Printing, South Lyon
- Seafood Restaurants, South Lyon
- Secondary Schools, South Lyon
- Security & Surveillance System & Equipment, South Lyon
- Security Brokers & Dealers, South Lyon
- Security Services, South Lyon
- Senior Citizens Service & Health Organizations, South Lyon
- Septic Tank Installation & Repair, South Lyon - Septic Systems
- Septic Tank Pumping & Cleaning, South Lyon - Septic Systems
- Septic Tanks & Septic Systems Contractors, South Lyon - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems Inspection, South Lyon
- Sewage Septic Service, South Lyon
- Sewer & Drain Cleaning & Repair, South Lyon - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, South Lyon
- Sharpening Service, South Lyon
- Shopping & Shopping Services, South Lyon
- Shuffleboards & Accessories, South Lyon
- Siding Contractors, South Lyon - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
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- Signs, South Lyon
- Snow Removal Services, South Lyon - Snow Plow Service
- Social Clubs & Organizations, South Lyon
- Social Services & Welfare, South Lyon
- Special Events & Party Supply Rental, South Lyon
- Special Interest Schools Or Instruction, South Lyon
- Specialty Animal Services, South Lyon
- Specialty Stores, South Lyon
- Speech & Hearing Specialists, South Lyon
- Speech Pathologists, South Lyon - Speech & Language Therapy
- Sporting Goods Equipment Rental, South Lyon
- Sporting Goods Stores, South Lyon
- Sports & Recreational Services, South Lyon
- Sports Bars & Lounges, South Lyon
- Sports Medicine, South Lyon - Doctors, Physicians & Surgeons
- Sportswear Clothing Stores, South Lyon - Sports Clothes
- Sportswear Manufacturers, South Lyon
- Sportswear Wholesale, South Lyon
- Stamp Collecting & Coin Dealers , South Lyon
- Stocks & Bond Brokers, South Lyon
- Stone Setting Contractors, South Lyon
- Stoves & Furnace Equipment, South Lyon - Fittings & Repair Parts
- Submarine Sandwich Restaurants, South Lyon
- Swimming Pools Repair, Service, Supplies, Sale & Installation, South Lyon
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