- Obstetricians & Gynecologists, Royal Oak - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Occupational Health Care Professionals, Royal Oak
- Occupational Therapy, Royal Oak - Occupational Health Specialists
- Office Furniture & Equipment Repair & Refinish, Royal Oak
- Office Supplies, Equipment & Office Furniture Stores, Royal Oak
- Oil & Grease Seals, Royal Oak
- Oil & Petroleum Products, Royal Oak - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Royal Oak - Auto Oil & Quick Lube
- Oil Industry & Oil Field Equipment & Services, Royal Oak - Oil Companies
- Oils Industrial, Royal Oak
- Old Age Homes Service, Royal Oak
- Oncologists, Royal Oak - Cancer Doctors, Physicians & Surgeons (Oncology)
- Ophthalmologists, Royal Oak - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Goods Repair & Service, Royal Oak - Camera Repair
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Royal Oak
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- Opticians, Royal Oak
- Optometrists, Royal Oak - Eye Doctors, Physicians & Surgeons (Optometry)
- Orchestras, Symphonies & Bands, Royal Oak
- Organs Tuning & Repair, Royal Oak
- Oriental Restaurants, Royal Oak
- Ornamental Nursery, Royal Oak
- Ornamental Nursery Services, Royal Oak
- Orthopedists, Royal Oak - Orthopedic Surgery Doctors, Physicians & Surgeons
- Other Building Materials & Supplies, Royal Oak
- Other Lodging, Royal Oak
- Outdoor & Lawn & Garden Equipment Repair & Service, Royal Oak
- Outdoor Centers, Royal Oak
- Outdoor Equipment & Accessories, Royal Oak
- Outpatient Services, Royal Oak - Outpatient Care
- Overhead Door, Royal Oak
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