- Salvation Army, Center Line
- Sandblasting, Center Line - General Contractors
- Sandwich Shop Restaurants, Center Line
- Satellite Dish Antennas & Equipment Dealers, Center Line
- Scientific Services, Center Line
- Secondary Schools, Center Line
- Secretarial & Court Reporting Services, Center Line
- Security Guard & Patrol Service, Center Line - Bodyguard, Guard Dogs, Etc
- Security Services, Center Line
- Sewer & Drain Cleaning & Repair, Center Line - Drain Cleaner & Installation Services
- Sewer Construction Contractors, Center Line - Sewer Line, Pipe Installation & Repair Services
- Shopping & Shopping Services, Center Line
- Snacks & Desserts, Center Line
- Snow Removal Services, Center Line - Snow Plow Service
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- Social Clubs & Organizations, Center Line
- Social Security And Disability Attorneys & Lawyers, Center Line
- Social Security And Disability Lawyers & Attorneys, Center Line
- Social Services & Welfare, Center Line
- Special Coatings, Center Line - Protective Coatings
- Specialty Stores, Center Line
- Speech & Hearing Specialists, Center Line
- Sporting Goods Equipment Rental, Center Line
- Staffing & Support Services, Center Line
- Stamp Collecting & Coin Dealers , Center Line
- Steel & Metal Goods, Center Line - Steel Distributors
- Stove, Oven, Range & Cooktop Parts & Supplies, Center Line
- Stoves & Furnace Equipment, Center Line - Fittings & Repair Parts
- Sweepers & Scrubbers Industrial, Center Line - Sweeping Service
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