- Sand Gravel & Aggregate, Jonesville
- Sandwich Shop Restaurants, Jonesville
- Satellite & Cable TV Equipment & Systems Repair & Service, Jonesville
- Satellite TV Service, Jonesville
- Savings & Loan Associations, Jonesville
- Savings Banks, Jonesville
- Scrap & Waste Materials, Jonesville
- Secondary Schools, Jonesville
- Security Brokers & Dealers, Jonesville
- Septic Tank Installation & Repair, Jonesville - Septic Systems
- Septic Tank Pumping & Cleaning, Jonesville - Septic Systems
- Septic Tanks & Septic Systems Contractors, Jonesville - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewing Contractors, Jonesville
- Sheet Metal, Jonesville
- Sheet Metal Contractors, Jonesville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Jonesville
- Shopping & Shopping Services, Jonesville
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- Signs, Jonesville
- Snacks & Desserts, Jonesville
- Snow Removal Equipment Repair & Service, Jonesville
- Social Services & Welfare, Jonesville
- Special Education & Care, Jonesville
- Specialty Stores, Jonesville
- Sporting Goods Stores, Jonesville
- Sports Medicine, Jonesville - Doctors, Physicians & Surgeons
- Staffing & Support Services, Jonesville
- State Government, Jonesville
- Steak House Restaurants, Jonesville
- Steel Erection Contractors, Jonesville - Steel Erectors
- Steel Manufacturers, Jonesville
- Stereo, Audio & Video Equipment Dealers & Stores, Jonesville
- Stocks & Bond Brokers, Jonesville
- Stoves & Furnace Equipment, Jonesville - Fittings & Repair Parts
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